Yes, provided the VTL supports iSeries-specific tape commands, not just generic SCSI tape emulation. AS400/IBM i shops rely on save commands like Option 21 and IPL-based saves, and backup software such as BRMS or Robot Save; a VTL built for that environment, like Cybernetics VTL, is tested against those specific commands rather than generic tape emulation alone. Confirm command-level compatibility with the specific VTL model before switching a production save process over.